IOX 2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IOX2 是缺氧诱导因子 (HIF) 脯氨酰羟化酶 (PHD) 的选择性抑制剂。

IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD); active in cells with IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM).(In Vitro):IOX2 (0, 10, 25, and 50 μM) dose-dependently inhibits collagen-related peptide (CRP; 0.25?μg/mL) or thrombin (0.03 U/mL)-induced platelet aggregation and ATP release. But IOX2 doesn’t affect P-selectin expression and the surface levels of glycoprotein (GP)Ibα, GPVI, or αIIbβ3.IOX2 also inhibits the spreading of platelets on fibrinogen or collagen and clot retraction.IOX2 (50 μM; 24 h) increases the transcription level of VEGF-A and BNIP3 in Normal human epidermal keratinocytes (NHEK) and Normal human dermal fibroblasts (NHDF), when grown under normoxia and hypoxia condition.(In Vivo):IOX2 (10 mg/kg; i.p.; single dose) impaired the in vivo hemostatic function of platelets and arterial thrombus formation in mice.

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Animal Model:Mouse Dosage:10 mg/kg Administration:Intraperitoneal injection Result:Upregulated HIF-1α in platelets, decreased ROS generation, and downregulated NOX1 expression.Increased the phosphorylation level of VASP (Ser157/239), and inhibited the phosphorylation of p38 (Thr180/Tyr182), ERK1/2 (Thr202/Tyr204), AKT (Thr308/Ser473), and PKCδ (Thr505) in CRP- or thrombin-stimulated platelets.

IOX2 | IOX-2 | IOX 2

Angiogenesis

HIF/HIF Prolyl-hydroxylase

PHD2

Cancer

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931398-72-0

352.34

C19H16N2O5

>98% (HPLC)

DMSO: 7 mg/mL (19.86 mM)

O=C(O)CNC(C1=C(O)C2=C(N(CC3=CC=CC=C3)C1=O)C=CC=C2)=O

N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine

(-20℃)

With Ice Pack

≥ 2 years